Issue 7, 2016
From the journal:

New Journal of Chemistry

RAPTA-C incorporation and controlled delivery from MIL-100(Fe) nanoparticles†

Sara Rojas,a   Francisco J. Carmona,a   Carmen R. Maldonado,a   Elisa Bareaa  and  Jorge A. R. Navarro*a  

* Corresponding authors

a Departamento de Química Inorgánica, Universidad de Granada, Av. Fuentenueva S/N, Granada, Spain
E-mail: jarn@ugr.es
Tel: +34 958 248 093

Abstract

[Fe3F(H2O)2O(btc)2]·nH2O (H3btc: benzene-1,3,5-tricarboxylic acid) (MIL-100(Fe)) in the form of nanoparticles with average size of 135 ± 70 nm can be used for the adsorption and controlled delivery of metallodrug [Ru(p-cymene)Cl2(pta)] (RAPTA-C) in simulated body fluid (SBF). The results show that the RAPTA-C delivery process takes place in two steps exhibiting half-life times of 1.9 and 30 h. We also found a positive effect of bovine serum albumine (BSA) in speeding up the RAPTA-C delivery rate, which agrees with the suitability of MIL-100(Fe) as a drug delivery system (DDS) for the controlled release of RAPTA-C.

Graphical abstract: RAPTA-C incorporation and controlled delivery from MIL-100(Fe) nanoparticles

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C5NJ02741A
Article type
Paper
Submitted
06 Oct 2015
Accepted
01 Dec 2015
First published
02 Dec 2015

New J. Chem., 2016,40, 5690-5694

Author version available

Download author version (PDF)

Permissions

Request permissions

RAPTA-C incorporation and controlled delivery from MIL-100(Fe) nanoparticles

S. Rojas, F. J. Carmona, C. R. Maldonado, E. Barea and J. A. R. Navarro, New J. Chem., 2016, 40, 5690 DOI: 10.1039/C5NJ02741A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements