Issue 18, 2016
From the journal:

Chemical Communications

Copper-mediated aerobic (phenylsulfonyl)difluoromethylation of arylboronic acids with difluoromethyl phenyl sulfone†

Xinjin Li,ab   Jingwei Zhao,b   Mingyou Hu,b   Dingben Chen,b   Chuanfa Ni,b   Limin Wang*a  and  Jinbo Hu*b  

* Corresponding authors

a Key Laboratory of Advanced Materials, Institute of Fine Chemicals, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China
E-mail: wanglimin@ecust.edu.cn

b Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
E-mail: jinbohu@sioc.ac.cn

Abstract

A new method for the generation of the “PhSO2CF2Cu” species from readily available difluoromethyl phenyl sulfone (PhSO2CF2H) has been developed. The “PhSO2CF2Cu” reagent can be applied in (phenylsulfonyl)difluoromethylation of arylboronic acids, which affords a convenient approach to introducing the PhSO2CF2 group into aromatics.

Graphical abstract: Copper-mediated aerobic (phenylsulfonyl)difluoromethylation of arylboronic acids with difluoromethyl phenyl sulfone

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Article information

DOI
https://doi.org/10.1039/C5CC10550A
Article type
Communication
Submitted
24 Dec 2015
Accepted
01 Feb 2016
First published
01 Feb 2016

Chem. Commun., 2016,52, 3657-3660

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Copper-mediated aerobic (phenylsulfonyl)difluoromethylation of arylboronic acids with difluoromethyl phenyl sulfone

X. Li, J. Zhao, M. Hu, D. Chen, C. Ni, L. Wang and J. Hu, Chem. Commun., 2016, 52, 3657 DOI: 10.1039/C5CC10550A

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