Carbon-based cores with polyglycerol shells – the importance of core flexibility for encapsulation of hydrophobic guests

Maike C. Lukowiak; Benjamin Ziem; Katharina Achazi; Gesine Gunkel-Grabole; Chris S. Popeney; Bala N. S. Thota; Christoph Böttcher; Anke Krueger; Zhibin Guan; Rainer Haag

doi:10.1039/C4TB01858C

Carbon-based cores with polyglycerol shells – the importance of core flexibility for encapsulation of hydrophobic guests†

Maike C. Lukowiak,^a Benjamin Ziem,^a Katharina Achazi,^a Gesine Gunkel-Grabole,^a Chris S. Popeney,^a Bala N. S. Thota,^a Christoph Böttcher,^a Anke Krueger,^b Zhibin Guan^c and Rainer Haag*^a

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* Corresponding authors

^a Institut für Chemie und Biochemie, Freie Universität Berlin, Takustr. 3, 14195 Berlin, Germany
E-mail: haag@chemie.fu-berlin.de

^b Institut für Organische Chemie, Julius-Maximilians-Universität Würzburg, Am Hubland, 97074 Würzburg, Germany

^c Department of Chemistry, University of California, 5042D Frederick Reines Hall, Irvine, California 92697-2025, USA

Abstract

Two core–shell nanoparticles with polyglycerol shells and sp³ carbon cores with different flexibilities (soft dendritic polyethylene and hard nanodiamond) were synthesized, their encapsulation capacities were compared, and their ability to transport into tumor cells was investigated. The nanocarrier with a soft core was superior to the hard one.

This article is part of the themed collection: 2015 Journal of Materials Chemistry B Hot Papers

Journal of Materials Chemistry B

Carbon-based cores with polyglycerol shells – the importance of core flexibility for encapsulation of hydrophobic guests†

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Carbon-based cores with polyglycerol shells – the importance of core flexibility for encapsulation of hydrophobic guests

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