Issue 20, 2014
From the journal:

Organic & Biomolecular Chemistry

Highly enantioselective Michael addition of diethyl malonate to chalcones catalyzed by cinchona alkaloids-derivatived bifunctional tertiary amine-thioureas bearing multiple hydrogen-bonding donors†

Yulong Liu,a   Xie Wang,a   Xiaoyun Wanga  and  Wei He*a  

* Corresponding authors

a Department of Chemistry, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, P. R. China
E-mail: weihechem@fmmu.edu.cn
Fax: +86 29 84774470
Tel: +86 29 84774470

Abstract

Chalcones are still challenge substrates in Michael reactions, and only limited success has been achieved. This work describes a highly enantioselective Michael addition of diethyl malonate with chalcones catalyzed by cinchona alkaloids-derivatived bifunctional tertiary amine-thioureas bearing multiple hydrogen-bonding donors.

Graphical abstract: Highly enantioselective Michael addition of diethyl malonate to chalcones catalyzed by cinchona alkaloids-derivatived bifunctional tertiary amine-thioureas bearing multiple hydrogen-bonding donors

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C4OB00203B
Article type
Communication
Submitted
26 Jan 2014
Accepted
20 Feb 2014
First published
21 Feb 2014

Org. Biomol. Chem., 2014,12, 3163-3166

Author version available

Download author version (PDF)

Permissions

Request permissions

Highly enantioselective Michael addition of diethyl malonate to chalcones catalyzed by cinchona alkaloids-derivatived bifunctional tertiary amine-thioureas bearing multiple hydrogen-bonding donors

Y. Liu, X. Wang, X. Wang and W. He, Org. Biomol. Chem., 2014, 12, 3163 DOI: 10.1039/C4OB00203B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements