Issue 12, 2014
From the journal:

Food & Function

Anticancer effects on human pancreatic cancer cells of triterpenoids, polysaccharides and 1,3-β-d-glucan derived from the fruiting body of Antrodia camphorata†

Chu-I. Lee,a   Chih-Chung Wu,b   Shu-Ling Hsieh,c   Chun-Lin Lee,d   Yueh-Ping Chang,e   Chih-Chuan Chang,f   Yi-Zhen Wangg  and  Jyh-Jye Wang*e  

* Corresponding authors

a Department of Medical Laboratory Science and Biotechnology, Fooyin University, 151 Jinxue Rd., Daliao Dist., Kaohsiung 83102, Taiwan, Republic of China

b Department of Nutrition and Health Sciences, Chang Jung Christian University, No. 1, Changda Rd., Gueiren District, Tainan City 71101, Taiwan, Republic of China

c Department of Seafood Sciences, National Kaohsiung Marine University, No. 142, Haijhuan Rd., Nanzih Dist., Kaohsiung 81157, Taiwan, Republic of China

d Department of Life Science, National Taitung University, 684 Sec. 1 Chunghua Rd., Taitung 95002, Taiwan, Republic of China

e Department of Nutrition and Health Science, Fooyin University, 151 Jinxue Rd., Daliao Dist., Kaohsiung 83102, Taiwan, Republic of China

f Sky Tree Biotechnology Co., Ltd, No. 16, Ln. 276, Sec. 1, Zhongshan Rd. Meinong Dist., Kaohsiung 843, Taiwan, Republic of China

g Graduate Institute of Biotechnology, Tajen University, No. 20, Weixin Rd., Yanpu Township, Pingtung County 90741, Taiwan, Republic of China
E-mail: ft054@fy.edu.tw
Fax: +886-7-7828701
Tel: +886-7-7811151 ext. 5464

Abstract

Antrodia camphorata is a fungus native to Taiwan, and it is considered a precious medicinal agent. We analyzed triterpenoids, polysaccharides and 1,3-β-D-glucan, three major effective components in A. camphorata extracts (ACE). ACE exhibited a selective cytotoxic effect on BxPC-3 human pancreatic cancer cells. ACE markedly inhibited the migration ability of BxPC-3 cells. Treatment of BxPC-3 cells with ACE resulted in the increase of cells in the sub-G1 phase and G2/M phase arrest. Apoptosis was confirmed by validating phosphatidylserine externalization, the observation of characteristic chromatin condensation, and nuclear DNA fragmentation. ACE induced apoptosis in BxPC-3 cells through a mitochondria-dependent pathway by triggering an appropriate balance of bax/bcl-2, cytochrome c release, activation of caspase-9 and -3, and poly(ADP-ribose) polymerase cleavage. ACE shows great therapeutic potential due to its cytotoxic effects against BxPC-3 cells which include inhibiting cell migration and inducing mitochondria-mediated apoptosis.

Graphical abstract: Anticancer effects on human pancreatic cancer cells of triterpenoids, polysaccharides and 1,3-β-d-glucan derived from the fruiting body of Antrodia camphorata

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Article information

DOI
https://doi.org/10.1039/C4FO00720D
Article type
Paper
Submitted
10 Aug 2014
Accepted
23 Sep 2014
First published
15 Oct 2014

Food Funct., 2014,5, 3224-3232

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Anticancer effects on human pancreatic cancer cells of triterpenoids, polysaccharides and 1,3-β-D-glucan derived from the fruiting body of Antrodia camphorata

Chu-I. Lee, C. Wu, S. Hsieh, C. Lee, Y. Chang, C. Chang, Y. Wang and J. Wang, Food Funct., 2014, 5, 3224 DOI: 10.1039/C4FO00720D

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