Issue 92, 2014

A dual functional AEE fluorogen as a mitochondrial-specific bioprobe and an effective photosensitizer for photodynamic therapy

Abstract

We report a dual functional aggregation-enhanced emission (AEE) molecule, TPE-IQ, which could target and illuminate mitochondria in both live and fixed cells with superb selectivity and high signal-to-noise ratio. More intriguingly, TPE-IQ can serve as a photosensitizer to generate reactive oxygen species (ROS) in the mitochondria region to induce cell apoptosis.

Graphical abstract: A dual functional AEE fluorogen as a mitochondrial-specific bioprobe and an effective photosensitizer for photodynamic therapy

Supplementary files

Article information

Article type
Communication
Submitted
10 Sep 2014
Accepted
26 Sep 2014
First published
26 Sep 2014

Chem. Commun., 2014,50, 14451-14454

Author version available

A dual functional AEE fluorogen as a mitochondrial-specific bioprobe and an effective photosensitizer for photodynamic therapy

E. Zhao, H. Deng, S. Chen, Y. Hong, C. W. T. Leung, J. W. Y. Lam and B. Z. Tang, Chem. Commun., 2014, 50, 14451 DOI: 10.1039/C4CC07128J

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