Issue 95, 2014
From the journal:

Chemical Communications

DNA cleavage by oxymyoglobin and cysteine-introduced metmyoglobin†

Megha Subhash Deshpande,a   Sendy Junedi,a   Halan Prakash,ab   Satoshi Nagao,a   Masaru Yamanakaa  and  Shun Hirota*a  

* Corresponding authors

a Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan
E-mail: hirota@ms.naist.jp
Fax: +81-743-72-6119

b Department of Chemistry, Birla Institute of Technology and Science, Pilani, K.K. Birla Goa Campus, Zuarinagar, Goa 403 726, India

Abstract

Double stranded DNA was cleaved oxidatively by incubation with oxygenated myoglobin, and Lys96Cys sperm whale myoglobin in its stable ferric form functioned as an artificial nuclease under air by formation of an oxygenated species, owing to electron transfer from the SH group of the introduced cysteine to the heme.

Graphical abstract: DNA cleavage by oxymyoglobin and cysteine-introduced metmyoglobin

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Article information

DOI
https://doi.org/10.1039/C4CC06617K
Article type
Communication
Submitted
22 Aug 2014
Accepted
10 Oct 2014
First published
10 Oct 2014

Chem. Commun., 2014,50, 15034-15036

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DNA cleavage by oxymyoglobin and cysteine-introduced metmyoglobin

M. S. Deshpande, S. Junedi, H. Prakash, S. Nagao, M. Yamanaka and S. Hirota, Chem. Commun., 2014, 50, 15034 DOI: 10.1039/C4CC06617K

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