Issue 12, 2013
From the journal:

Nanoscale

Surface-engineered nanomaterials as X-ray absorbing adjuvant agents for Auger-mediated chemo-radiation†

Sang-Min Lee,‡ab   De-Hao Tsai,a   Vincent A. Hackley,a   Martin W. Brechbielb  and  Robert F. Cook*a  

* Corresponding authors

a Material Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, USA
E-mail: robert.cook@nist.gov

b National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA

Abstract

We report a prototype approach to formulate gold nanoparticle-based X-ray absorbing agents through surface-engineering of a cisplatin pharmacophore with modified polyacrylate. The resulting agents exhibit both chemo-therapeutic potency to cancer cells and Auger-mediated secondary electron emission, showing great potential to improve the therapeutic efficacy of chemo-radiation.

Graphical abstract: Surface-engineered nanomaterials as X-ray absorbing adjuvant agents for Auger-mediated chemo-radiation

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Article information

DOI
https://doi.org/10.1039/C3NR00333G
Article type
Communication
Submitted
18 Jan 2013
Accepted
11 Apr 2013
First published
30 Apr 2013

Nanoscale, 2013,5, 5252-5256

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Surface-engineered nanomaterials as X-ray absorbing adjuvant agents for Auger-mediated chemo-radiation

S. Lee, D. Tsai, V. A. Hackley, M. W. Brechbiel and R. F. Cook, Nanoscale, 2013, 5, 5252 DOI: 10.1039/C3NR00333G

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