Issue 72, 2013
From the journal:

Chemical Communications

Easy access to enamides: a mild nickel-catalysed alkene isomerization of allylamides†

Lu Wang,‡a   Chao Liu,‡a   Ruopeng Bai,a   Yani Pana  and  Aiwen Lei*ab  

* Corresponding authors

a College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China
E-mail: aiwenlei@whu.edu.cn
Fax: +86-27-68754067
Tel: +86-27-68754672

b Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, P. R. China

Abstract

The first Ni-catalysed alkene isomerization of allylamides for the synthesis of enamides was demonstrated. Various substituted N-allylamides were found to be suitable substrates for this isomerization. Isotopic labelling experiments showed that it is an intramolecular hydrogen transfer process.

Graphical abstract: Easy access to enamides: a mild nickel-catalysed alkene isomerization of allylamides

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Article information

DOI
https://doi.org/10.1039/C3CC43875A
Article type
Communication
Submitted
23 May 2013
Accepted
28 Jun 2013
First published
01 Jul 2013

Chem. Commun., 2013,49, 7923-7925

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Easy access to enamides: a mild nickel-catalysed alkene isomerization of allylamides

L. Wang, C. Liu, R. Bai, Y. Pan and A. Lei, Chem. Commun., 2013, 49, 7923 DOI: 10.1039/C3CC43875A

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