Issue 4, 1990

Enantiospecific synthesis of 2-crotonyloxy-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC) from quinic acid

Abstract

A thirteen-step synthesis of the glyoxalase I inhibitor COTC [2-Crotonyloxy-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone] from quinic acid is described.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1990, 312-312

Enantiospecific synthesis of 2-crotonyloxy-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC) from quinic acid

T. K. M. Shing and Y. Tang, J. Chem. Soc., Chem. Commun., 1990, 312 DOI: 10.1039/C39900000312

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