Issue 40, 2012
From the journal:

Soft Matter

Structure and function of ECM-inspired composite collagen type I scaffolds

Dimitar R. Stamova  and  Tilo Pompe*b  

* Corresponding authors

a Karlsruhe Institute of Technology (KIT), DFG-Center for Functional Nanostructures, Wolfgang-Gaede-Strasse 1a, 76131 Karlsruhe, Germany
E-mail: dimitar.stamov@kit.edu
Fax: +49 721 6084 8496
Tel: +49 721 6084 5803

b Universität Leipzig, Institute of Biochemistry, Johannisallee 21-23, 04103 Leipzig, Germany
E-mail: tilo.pompe@uni-leipzig.de
Fax: +49 341 9736 939
Tel: +49 341 9736 931

Abstract

Collagen I is one of the most abundant molecules in vertebrates constituting major parts of the fibrillar extracellular matrix (ECM), thus providing structural integrity and mechanical resilience. It has therefore become an almost ubiquitous biomolecule to use in contemporary biomimetic cell culture scaffolds and in tissue engineering scenarios where new functions for biomedical applications are sought. As collagen I easily self-assembles into fibrillar structures, a number of approaches aim to integrate new functionalities by varying the compositional complexity of the developed scaffolds. Such composite matrices make use of the abundant knowledge about the fibrillar collagen I structure and its binding sites for other ECM molecules. This review gives an overview of the reconstitution of collagen I scaffolds by the implementation of other organic biomolecules. We focus on the self-assembly and structure of the collagen I fibrils affected by the interaction with cofactors and comment on mechanics and biomedical use of such composite scaffolds.

Graphical abstract: Structure and function of ECM-inspired composite collagen type I scaffolds

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Article information

DOI
https://doi.org/10.1039/C2SM26134K
Article type
Review Article
Submitted
16 May 2012
Accepted
29 Jun 2012
First published
23 Jul 2012

Soft Matter, 2012,8, 10200-10212

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Structure and function of ECM-inspired composite collagen type I scaffolds

D. R. Stamov and T. Pompe, Soft Matter, 2012, 8, 10200 DOI: 10.1039/C2SM26134K

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