Effect of the nanoparticle synthesis method on dendronized iron oxides as MRI contrast agents

Brice Basly; Gabriela Popa; Solenne Fleutot; Benoit P. Pichon; Antonio Garofalo; Cynthia Ghobril; Claire Billotey; Aurélie Berniard; Pauline Bonazza; Hervé Martinez; Delphine Felder-Flesch; Sylvie Begin-Colin

doi:10.1039/C2DT31788E

Effect of the nanoparticle synthesis method on dendronized iron oxides as MRI contrast agents†

Brice Basly,^a Gabriela Popa,^a Solenne Fleutot,^a Benoit P. Pichon,^a Antonio Garofalo,^a Cynthia Ghobril,^a Claire Billotey,^bc Aurélie Berniard,^b Pauline Bonazza,^b Hervé Martinez,^d Delphine Felder-Flesch*^a and Sylvie Begin-Colin*^a

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* Corresponding authors

^a Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), UMR 7504, CNRS, Université de Strasbourg, 23, rue du Loess, BP 43, 67034 Strasbourg Cedex 2, France
E-mail: sylvie.begin@ipcms.unistra.fr, delphine.felder@ipcms.unistra.fr
Fax: +33 (0)3 88 10 72 47
Tel: +33 (0)3 88 10 71 92

^b Laboratoire de Physico-Chimie des Matériaux Luminescents, UMR 5620 CNRS-UCBL, Université Claude Bernard Lyon1, 10 rue Ada Byron, 69622 Villeurbanne cedex, France

^c Hospices Civils de Lyon – Service de Médecine Nucléaire Pavillon B, 5 place d'Arsonval, 69437 Lyon cedex 03, France

^d IPREM ECP – UMR 5254, Université de Pau et des Pays de l'Adour, Hélioparc Pau-Pyrénées, 2 Av du Président Angot, 64053 Pau Cedex 9, France

Abstract

Aqueous suspensions of dendronized iron oxide nanoparticles (NPs) have been obtained after functionalization, with two types of dendrons, of NPs synthesized either by coprecipitation (leading to naked NPs in water) or by thermal decomposition (NPs in situ coated by oleic acid in an organic solvent). Different grafting strategies have been optimized depending on the NPs synthetic method. The size distribution, the colloidal stability in isoosmolar media, the surface complex nature as well as the preliminary biokinetic studies performed with optical imaging, and the contrast enhancement properties evaluated through in vitro and in vivo MRI experiments, have been compared as a function of the nature of both dendrons and NPs. All functionalized NPs displayed good colloidal stability in water, however the ones bearing a peripheral carboxylic acid function gave the best results in isoosmolar media. Whereas the grafting rates were similar, the nature of the surface complex depended on the NPs synthetic method. The in vitro contrast enhancement properties were better than commercial products, with a better performance of the NPs synthesized by coprecipitation. On the other hand, the NPs synthesized by thermal decomposition were more efficient in vivo. Furthermore, they both displayed good biodistribution with renal and hepatobiliary elimination pathways and no consistent RES uptake.

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Effect of the nanoparticle synthesis method on dendronized iron oxides as MRI contrast agents†

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Effect of the nanoparticle synthesis method on dendronized iron oxides as MRI contrast agents

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