Issue 3, 2011
From the journal:

Polymer Chemistry

Shedding the hydrophilic mantle of polymersomes†

René P. Brinkhuis,*a   Taco R. Visser,a   Floris P. J. T. Rutjesa  and  Jan C. M. van Hesta  

* Corresponding authors

a Radboud University Nijmegen, Institute for Molecules and Materials, Heyendaalseweg 135, Nijmegen, The Netherlands
E-mail: f.rutjes@science.ru.nl, j.vanhest@science.ru.nl
Fax: +31 243653393
Tel: +31 243653204

Abstract

Block copolymers of polybutadiene-b-poly(ethylene glycol) were prepared in which both segments were coupled via an acid sensitive hydrazone moiety. Polymersomes that were subsequently formed showed a strong pH-dependent colloidal stability as a result of the pH sensitive removal of the PEG block. By mixing this stimulus responsive block polymer with an inert analogue it was possible to systematically remove percentages of PEG from the polymersome mantle. The minimum amount of surface PEGylation needed to retain stable polymersomes was found to be as low as five percent.

Graphical abstract: Shedding the hydrophilic mantle of polymersomes

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Article information

DOI
https://doi.org/10.1039/C0PY00316F
Article type
Communication
Submitted
23 Sep 2010
Accepted
26 Oct 2010
First published
16 Nov 2010

Polym. Chem., 2011,2, 550-552

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Shedding the hydrophilic mantle of polymersomes

R. P. Brinkhuis, T. R. Visser, F. P. J. T. Rutjes and J. C. M. van Hest, Polym. Chem., 2011, 2, 550 DOI: 10.1039/C0PY00316F

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