Issue 3, 2011
From the journal:

Journal of Materials Chemistry

Multi-walled carbon nanotubes as an effective fluorescent sensing platform for nucleic acid detection

Hailong Li,ab   Jingqi Tian,ab   Lei Wang,a   Yingwei Zhanga  and  Xuping Sun*a  

* Corresponding authors

a State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, China
E-mail: sunxp@ciac.jl.cn.
Fax: +86-431-85262065
Tel: +86-431-85262065

b Graduate School of the Chinese Academy of Sciences, Beijing, China

Abstract

In this article, we report on the use of multi-walled carbon nanotubes (MWCNTs) as an effective fluorescent sensing platform for nucleic acid detection with selectivity down to single-base mismatch. The detection is accomplished with two steps: (1) MWCNTs adsorb and quench the fluorescence of the dye-labeled single-stranded DNA (ssDNA) probe; (2) in the presence of the target, a hybridization event occurs, which produces a double-stranded DNA (dsDNA) that detaches from the MWCNT surface, leading to the restoration of the dye fluorescence. We also compared the sensing responses of MWCNTs and single-walled carbon nanotubes (SWCNTs) under the same experimental conditions.

Graphical abstract: Multi-walled carbon nanotubes as an effective fluorescent sensing platform for nucleic acid detection

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Article information

DOI
https://doi.org/10.1039/C0JM02695F
Article type
Paper
Submitted
16 Aug 2010
Accepted
19 Oct 2010
First published
09 Nov 2010

J. Mater. Chem., 2011,21, 824-828

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Multi-walled carbon nanotubes as an effective fluorescent sensing platform for nucleic acid detection

H. Li, J. Tian, L. Wang, Y. Zhang and X. Sun, J. Mater. Chem., 2011, 21, 824 DOI: 10.1039/C0JM02695F

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