Issue 1, 2010
From the journal:

Natural Product Reports

Biosynthesis and biomimetic synthesis of alkaloids isolated from plants of the Nitraria and Myrioneuron genera: an unusual lysine-based metabolism

Edmond Gravela  and  Erwan Poupon*a  

* Corresponding authors

a Laboratoire de Pharmacognosie associé au CNRS, UMR 8076 (BioCIS), Centre d'Études Pharmaceutiques, Université Paris-Sud 11, 5 rue Jean-Baptiste Clément, Châtenay-Malabry, France
E-mail: erwan.poupon@u-psud.fr

Abstract

Covering: up to November 2009

This review describes a wide panel of alkaloids isolated from plants of the Nitraria genus, focusing on their biosynthesis and discussing the resulting biomimetic chemistry in relevant cases. The scope is purposely limited to alkaloids derived at least to some extent from L-lysine, considering that most of these molecules have unique structures and are specific to the genus. Some of the biosynthetic pathways described are taken from the literature, but others are proposed here for the first time. The latter are mostly hypotheses justified by the fact that they are based on metabolic routes frequently encountered for other Nitraria alkaloids, and thus permit unification of the biosynthesis around common pivotal biosynthetic intermediates. Myrioneuron alkaloids are also presented as a newly discovered class with striking similarities to Nitraria alkaloids.

Graphical abstract: Biosynthesis and biomimetic synthesis of alkaloids isolated from plants of the Nitraria and Myrioneuron genera: an unusual lysine-based metabolism

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Article information

DOI
https://doi.org/10.1039/B911866G
Article type
Review Article
Submitted
17 Jun 2009
First published
17 Nov 2009

Nat. Prod. Rep., 2010,27, 32-56

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Biosynthesis and biomimetic synthesis of alkaloids isolated from plants of the Nitraria and Myrioneuron genera: an unusual lysine-based metabolism

E. Gravel and E. Poupon, Nat. Prod. Rep., 2010, 27, 32 DOI: 10.1039/B911866G

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