Issue 45, 2009

Iodine-mediated cyclization of N-thioacyl-1-(2-pyridyl)-1,2-aminoalcohols and their subsequent condensation leading to the formation of novel bis(1-imidazo[1,5-a]pyridyl)arylmethanes

Abstract

The treatment of N-thioacyl-1-(2-pyridyl)-1,2-aminoalcohols with iodine and pyridine in THF at room temperature for 30 min leads to the formation of bis(1-imidazo[1,5-a]pyridyl)arylmethanes as green solids in good to high yields.

Graphical abstract: Iodine-mediated cyclization of N-thioacyl-1-(2-pyridyl)-1,2-aminoalcohols and their subsequent condensation leading to the formation of novel bis(1-imidazo[1,5-a]pyridyl)arylmethanes

Supplementary files

Article information

Article type
Communication
Submitted
22 May 2009
Accepted
23 Sep 2009
First published
13 Oct 2009

Chem. Commun., 2009, 7009-7011

Iodine-mediated cyclization of N-thioacyl-1-(2-pyridyl)-1,2-aminoalcohols and their subsequent condensation leading to the formation of novel bis(1-imidazo[1,5-a]pyridyl)arylmethanes

S. Tahara, F. Shibahara, T. Maruyama and T. Murai, Chem. Commun., 2009, 7009 DOI: 10.1039/B910172A

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