Issue 4, 2005
From the journal:

Organic & Biomolecular Chemistry

The dynamic properties of an intramolecular transition from DNA duplex to cytosine–thymine motif triplex

Marco Brucale,a   Giampaolo Zuccheri*a  and  Bruno Samorìa  

* Corresponding authors

a Department of Biochemistry “G. Moruzzi” and National Institute for the Physics of the Matter, University of Bologna, Via Irnerio 48, Bologna
Fax: (+39)-051-2094387

Abstract

We here report that the formation and breakdown of an intramolecular cytosine–thymine (CT) motif DNA triple-helix can be performed repeatedly, quickly and independently of its local concentration without performance reduction over successive cycles; as a consequence, we propose that this set of characteristics makes the DNA duplex–triplex transition an ideal candidate to power simple nanometer-scale devices capable of maintaining effective performance regardless of their local concentration.

Graphical abstract: The dynamic properties of an intramolecular transition from DNA duplex to cytosine–thymine motif triplex

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Article information

DOI
https://doi.org/10.1039/B418353N
Article type
Communication
Submitted
06 Dec 2004
Accepted
06 Dec 2004
First published
05 Jan 2005

Org. Biomol. Chem., 2005,3, 575-577

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The dynamic properties of an intramolecular transition from DNA duplex to cytosine–thymine motif triplex

M. Brucale, G. Zuccheri and B. Samorì, Org. Biomol. Chem., 2005, 3, 575 DOI: 10.1039/B418353N

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