Issue 8, 2005
From the journal:

Chemical Communications

Saccharin as a salt former. Enhanced solubilities of saccharinates of active pharmaceutical ingredients†

Prashant M. Bhatt,a   Nittala V. Ravindra,b   Rahul Banerjeea  and  Gautam R. Desiraju*a  

* Corresponding authors

a School of Chemistry, University of Hyderabad, Hyderabad 500 046, India
E-mail: gautam_desiraju@yahoo.com

b Informatics Division, GVK BIOSCIENCES Private Limited, 6-3-1192, Begumpet, Hyderabad 500 016, India

Abstract

Saccharin, acting as a weak acid, forms salts with basic APIs and these salts have the desirable property of enhanced water solubility.

Graphical abstract: Saccharin as a salt former. Enhanced solubilities of saccharinates of active pharmaceutical ingredients

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Article information

DOI
https://doi.org/10.1039/B416137H
Article type
Communication
Submitted
19 Oct 2004
Accepted
29 Nov 2004
First published
12 Jan 2005

Chem. Commun., 2005, 1073-1075

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Saccharin as a salt former. Enhanced solubilities of saccharinates of active pharmaceutical ingredients

P. M. Bhatt, N. V. Ravindra, R. Banerjee and G. R. Desiraju, Chem. Commun., 2005, 1073 DOI: 10.1039/B416137H

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