Issue 53, 2016
From the journal:

Chemical Communications

“Smart” gold nanoparticles for photoacoustic imaging: an imaging contrast agent responsive to the cancer microenvironment and signal amplification via pH-induced aggregation†

Jaejung Song,‡a   Jeesu Kim,‡b   Sekyu Hwang,c   Mansik Jeon,d   Sanghwa Jeong,c   Chulhong Kim*b  and  Sungjee Kim*ac  

* Corresponding authors

a School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang University of Science and Technology (POSTECH), 77 Cheongam Ro, Nam Gu, Pohang, South Korea
E-mail: sungjee@postech.ac.kr

b Department of Electrical Engineering and Creative IT Engineering, POSTECH, Pohang, South Korea
E-mail: chulhong@postech.edu

c Department of Chemistry, POSTECH, Pohang, South Korea

d School of Electronics Engineering College of IT Engineering, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, South Korea

Abstract

‘Smart’ gold nanoparticles can respond to mild acidic environments, rapidly form aggregates, and shift the absorption to red and near-infrared. They were used as a photoacoustic imaging agent responsive to the cancer microenvironment, and have demonstrated the cancer-specific accumulation at the cellular level and an amplified signal which is twice higher than the control in vivo.

Graphical abstract: “Smart” gold nanoparticles for photoacoustic imaging: an imaging contrast agent responsive to the cancer microenvironment and signal amplification via pH-induced aggregation

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Article information

DOI
https://doi.org/10.1039/C6CC03100E
Article type
Communication
Submitted
13 Apr 2016
Accepted
06 Jun 2016
First published
13 Jun 2016

Chem. Commun., 2016,52, 8287-8290

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“Smart” gold nanoparticles for photoacoustic imaging: an imaging contrast agent responsive to the cancer microenvironment and signal amplification via pH-induced aggregation

J. Song, J. Kim, S. Hwang, M. Jeon, S. Jeong, C. Kim and S. Kim, Chem. Commun., 2016, 52, 8287 DOI: 10.1039/C6CC03100E

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