Issue 83, 2014

Natural halloysite nanotubes modified as an aspirin carrier

Abstract

Natural halloysite nanotubes (HNTs) modified with 3-aminopropyltriethoxysilane were used as an aspirin carrier. The structure, drug loading and release profiles of samples were characterized by X-ray diffraction (XRD), thermogravimetry-differential scanning calorimetry (TG-DSC), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR) and UV-spectrophotometry. The Higuchi model Q = kt0.5 was employed to analyze the dissolution data in detail. The results indicated that the modification of HNTs could improve the amount of aspirin from 3.84 to 11.98 wt%. The physical state of aspirin was nanocrystalline and amorphous affected by the confined space of HNTs, which significantly enhanced the dissolution rate created by a burst release within the first hour. The linearity of the Higuchi equation indicated that the aspirin release mechanism for modified HNTs was fitted to Fick's diffusion and the dissolution rate was slower than that of natural HNTs. The as-synthesized N-HNTs could have interesting potential application in drug carrier systems.

Graphical abstract: Natural halloysite nanotubes modified as an aspirin carrier

Article information

Article type
Paper
Submitted
26 Aug 2014
Accepted
03 Sep 2014
First published
05 Sep 2014

RSC Adv., 2014,4, 44197-44202

Author version available

Natural halloysite nanotubes modified as an aspirin carrier

H. Lun, J. Ouyang and H. Yang, RSC Adv., 2014, 4, 44197 DOI: 10.1039/C4RA09006C

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