Issue 10, 2011
From the journal:

Nanoscale

Fullerene C60 as a multifunctional system for drug and gene delivery

Alejandro Montellano,a   Tatiana Da Ros,a   Alberto Biancob  and  Maurizio Prato*a  

* Corresponding authors

a Center of Excellence for Nanostructured Materials (CENMAT), Department of Chemical and Pharmaceutical Sciences, and INSTM, Unit of Trieste University of Trieste, Piazzale Europa 1, Trieste, Italy
E-mail: prato@units.it

b CNRS, Institut de Biologie Moléculaire et Cellulaire, Laboratoire d'Immunologie et Chimie Thérapeutiques, UPR 9021, Strasbourg, France

Abstract

The fullerene family, and especially C60, has delighted the scientific community during the last 25 years with perspective applications in a wide variety of fields, including the biological and the biomedical domains. Several biomedical uses have been explored using water-soluble C60-derivatives. However, the employment of fullerenes for drug delivery is still at an early stage of development. The design and synthesis of multifunctionalized and multimodal C60 systems able to cross the cell membranes and efficiently deliver active molecules is an attracting challenge that involves multidisciplinary strategies. Promising results have emerged in the last years, bringing fullerenes again to the front of interest. Herein, the state of the art of this emerging field is presented and illustrated with some of the most representative examples.

Graphical abstract: Fullerene C60 as a multifunctional system for drug and gene delivery

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Article information

DOI
https://doi.org/10.1039/C1NR10783F
Article type
Feature Article
Submitted
10 Jul 2011
Accepted
24 Jul 2011
First published
07 Sep 2011

Nanoscale, 2011,3, 4035-4041

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Fullerene C60 as a multifunctional system for drug and gene delivery

A. Montellano, T. Da Ros, A. Bianco and M. Prato, Nanoscale, 2011, 3, 4035 DOI: 10.1039/C1NR10783F

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