Issue 9, 2011
From the journal:

Journal of Materials Chemistry

NIR-emitting fluorescent gold nanoclusters doped in silica nanoparticles†

Xavier Le Guével,*a   Benjamin Hötzer,b   Gregor Jungb  and  Marc Schneidera  

* Corresponding authors

a Pharmaceutical Nanotechnology, Saarland University, Saarbrücken, Germany
E-mail: x.leguevel@mx.uni-saarland.de

b Department of Biophysical Chemistry, Saarland University, Saarbrücken, Germany

Abstract

In this paper we describe the synthesis and the optimisation of a new family of fluorescent core–shell nanoparticle using protein-stabilised gold nanoclusters. Fluorescent gold nanoclusters (<2 nm) entrapped in bovine serum albumin (BSA) protein were loaded in a 100 nm-silica nanoparticle with an optimal concentration of 3% (w/w). These nanoparticles kept the fluorescence properties of the metal clusters with a high Stokes shift and an emission in the near infrared region (λ = 670 nm). They were fully characterized and showed a high monodispersity and stability over more than 5 months. Steady-state fluorescence and lifetime measurements indicate the role of silica as a protective host to improve the photostability and the chemical stability of the fluorescent compound. This new label was taken up in tumor lung cells and tracked by a confocal microscope to show the great potential of this biolabel for sensing and imaging.

Graphical abstract: NIR-emitting fluorescent gold nanoclusters doped in silica nanoparticles

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Article information

DOI
https://doi.org/10.1039/C0JM02660C
Article type
Paper
Submitted
13 Aug 2010
Accepted
13 Dec 2010
First published
24 Jan 2011

J. Mater. Chem., 2011,21, 2974-2981

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NIR-emitting fluorescent gold nanoclusters doped in silica nanoparticles

X. Le Guével, B. Hötzer, G. Jung and M. Schneider, J. Mater. Chem., 2011, 21, 2974 DOI: 10.1039/C0JM02660C

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