Issue 48, 2009
From the journal:

Dalton Transactions

Microwave synthesis of mixed ligand diimine–thiosemicarbazone complexes of ruthenium(ii): biophysical reactivity and cytotoxicity†

Floyd A. Beckford,*a   Michael Shaloski, Jr.,a   Gabriel Leblanc,a   Jeffrey Thessing,a   Lesley C. Lewis-Alleyne,b   Alvin A. Holder,b   Liya Lic  and  Navindra P. Seeramc  

* Corresponding authors

a Science Division, Lyon College, Batesville, AR, USA
E-mail: floyd.beckford@lyon.edu
Fax: +1 (870) 307-7496
Tel: +1 (870) 307-7212

b Department of Chemistry and Biochemistry, The University of Southern Mississippi, 118 College Drive, # 5043, Hattiesburg, Mississippi, USA

c Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy University of Rhode Island, Kingston, RI, USA

Abstract

A novel microwave-assisted synthetic method has been used to synthesise a series of mixed ligand ruthenium(II) compounds containing diimine as well as bidentate thiosemicarbazone ligands. The compounds contain the diimine 1,10-phenanthroline (phen) or 2,2′-bipyridine (bpy) and the thiosemicarbazone is derived from 9-anthraldehyde. Based on elemental analyses and spectroscopic data, the compounds are best formulated as [(phen)2Ru(thiosemicarbazone)](PF6)2 and [(phen)2Ru(thiosemicarbazone)](PF6)2 where thiosemicarbazone = 9-anthraldehydethiosemicarbazone, 9-anthraldehyde-N(4)-methylthiosemicarbazone, and 9-anthraldehyde-N(4)-ethylthiosemicarbazone. Fluorescence competition studies with ethidium bromide, along with viscometric measurements suggests that the complexes bind calf thymus DNA (CTDNA) relatively strongly via an intercalative mode possibly involving the aromatic rings of the diimine ligands. The complexes show good cytotoxic profiles against MCF-7 and MDA-MB-231 (breast adenocarcinoma) as well as HCT 116 and HT-29 (colorectal carcinoma) cell lines.

Graphical abstract: Microwave synthesis of mixed ligand diimine–thiosemicarbazone complexes of ruthenium(ii): biophysical reactivity and cytotoxicity

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B915081A
Article type
Paper
Submitted
27 Jul 2009
Accepted
15 Sep 2009
First published
28 Sep 2009

Dalton Trans., 2009, 10757-10764

Permissions

Request permissions

Microwave synthesis of mixed ligand diimine–thiosemicarbazone complexes of ruthenium(II): biophysical reactivity and cytotoxicity

F. A. Beckford, M. Shaloski, Jr., G. Leblanc, J. Thessing, L. C. Lewis-Alleyne, A. A. Holder, L. Li and N. P. Seeram, Dalton Trans., 2009, 10757 DOI: 10.1039/B915081A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements