Issue 6, 2002
From the journal:

Analyst

The determination of 5 anticoccidial drugs (nicarbazin, lasalocid, monensin, salinomycin and narasin) in animal livers and eggs by liquid chromatography linked with tandem mass spectrometry (LC-MS-MS)

Dharmendr K. Matabudul,a   Ian D. Lumleya  and  John S. Points*a  

* Corresponding authors

a Veterinary Drugs Group, LGC, Middlesex, Teddington, UK

Abstract

A method has been developed for the simultaneous extraction and determination of five of the most commonly used anticoccidial drugs (nicarbazin, lasalocid, monensin, narasin and salinomycin) from livers and eggs by LC-MS-MS. Results show good repeatability, with mean spiked recoveries for nicarbazin, lasalocid, monensin, narasin and salinomycin in poultry livers in the average range of 92–118%, and 86–110% in eggs. The detection limit is at 1 ng ml−1 for all the named compounds and a quantitation level of 2.5 ng g−1 has been achieved. A high throughput of samples is achievable using this method which allows the analysis of up to 40 samples by one analyst in a day.

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Article information

DOI
https://doi.org/10.1039/B200872F
Article type
Paper
Submitted
23 Jan 2002
Accepted
03 Apr 2002
First published
07 May 2002

Analyst, 2002,127, 760-768

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The determination of 5 anticoccidial drugs (nicarbazin, lasalocid, monensin, salinomycin and narasin) in animal livers and eggs by liquid chromatography linked with tandem mass spectrometry (LC-MS-MS)

D. K. Matabudul, I. D. Lumley and J. S. Points, Analyst, 2002, 127, 760 DOI: 10.1039/B200872F

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