Issue 5, 1974
From the journal:

Journal of the Chemical Society, Perkin Transactions 2

Crystal and molecular structure of acetazolamide (5-acetamido-1,3,4-thiadiazole-2-sulphonamide), a potent inhibitor of carbonic anhydrase

Mathai Mathew  and  Gus J. Palenik  

Abstract

Crystals of the title compound, a potent inhibitor of carbonic anhydrase, are colourless, triclinic, with unit-cell dimensions, a= 5·318(4), b= 9·065(4), c= 9·430(7)Å, α= 105·44(2), β= 98·59(2), γ= 100·42(2)°, Z= 2. The structures was solved by the heavy-atom method and refined by least-squares techniques to a final R of 0·028 for 1054 observed reflections. The distances and angles are compared with those in other sulphonamides of varying biological activity. The mechanism of inhibition of carbonic anhydrase is discussed.

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Article information

DOI
https://doi.org/10.1039/P29740000532
Article type
Paper

J. Chem. Soc., Perkin Trans. 2, 1974, 532-536

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Crystal and molecular structure of acetazolamide (5-acetamido-1,3,4-thiadiazole-2-sulphonamide), a potent inhibitor of carbonic anhydrase

M. Mathew and G. J. Palenik, J. Chem. Soc., Perkin Trans. 2, 1974, 532 DOI: 10.1039/P29740000532

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