Issue 21, 1977

Amino-acids and peptides. Part 19. Conformational studies of the monamycins, a family of cyclohexadepsipeptide antibiotics

Abstract

Evidence derived largely from studies of monamycins D1 and H1 in solution using 1H n.m.r., 13C n.m.r., and i.r. spectroscopy supports a single conformation (Figure 6) for each congener. It incorporates a β-loop with hydrogen bonding of the NH groups of the Val residue to the carbonyl of the hydroxypiperazic acid residue.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1977, 2369-2376

Amino-acids and peptides. Part 19. Conformational studies of the monamycins, a family of cyclohexadepsipeptide antibiotics

C. H. Hassall, W. A. Thomas and M. C. Moschidis, J. Chem. Soc., Perkin Trans. 1, 1977, 2369 DOI: 10.1039/P19770002369

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