Facile Friedel–Crafts alkylation of arenes under solvent-free conditions†
Yan-Na
Ma 
*a
and
Xuenian
Chen
*a
*a
and
Xuenian
Chen
*a
Abstract
The Friedel–Crafts alkylation of arenes is an important part of electrophilic aromatic substitution reactions. However, the reactivity of arenes is weakened by electron-withdrawing substituents, leading to limited substrate scopes and applications. Herein, we developed an efficient HOTf-promoted Friedel–Crafts alkylation reaction of broad arenes with α-aryl-α-diazoesters under metal-free and solvent-free conditions.
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