Issue 48, 2023
From the journal:

Organic & Biomolecular Chemistry

Preparation of pyridopyrazines through tandem Pd-catalyzed C–N/C–C coupling reactions of Ugi adducts†

Ahmad Takallou, ORCID logo *a   Munir Al-Siyabi,a   Sulaiman Al-Shidhani,a   Yazdanbakhsh Lotfi Nosood,a   Azizollah Habibi, ORCID logo b   Alhajaj Almaani,a   Muhammad U. Anwar ORCID logo a  and  Ahmed Al-Harrasi*a  

* Corresponding authors

a Natural and Medical Sciences Research Center, University of Nizwa, P.O. Box 33, Postal Code 616, Birkat Al Mauz, Nizwa, Sultanate of Oman
E-mail: ahmadtak@unizwa.edu.om, aharrasi@unizwa.edu.om

b Faculty of Chemistry, Kharazmi University, Daneshgah Square, Shahid Beheshti Street, 31979-37551, Karaj, Iran

Abstract

A Pd-catalyzed selective tandem cyclization of the Ugi adduct via Buchwald–Hartwig/C–H bond functionalization reactions has been reported. This sequence offers an interesting approach for synthesizing a wide range of pyrido[1,2-a]pyrazine-3,6-dione scaffolds under mild reaction conditions in moderate to excellent yields. The scope and limitations of the protocol are discussed.

Graphical abstract: Preparation of pyridopyrazines through tandem Pd-catalyzed C–N/C–C coupling reactions of Ugi adducts

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Article information

DOI
https://doi.org/10.1039/D3OB01768K
Article type
Communication
Submitted
28 Oct 2023
Accepted
23 Nov 2023
First published
23 Nov 2023

Org. Biomol. Chem., 2023,21, 9530-9533

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Preparation of pyridopyrazines through tandem Pd-catalyzed C–N/C–C coupling reactions of Ugi adducts

A. Takallou, M. Al-Siyabi, S. Al-Shidhani, Y. Lotfi Nosood, A. Habibi, A. Almaani, M. U. Anwar and A. Al-Harrasi, Org. Biomol. Chem., 2023, 21, 9530 DOI: 10.1039/D3OB01768K

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