Issue 43, 2023
From the journal:

Organic & Biomolecular Chemistry

Synthesis of 3(2H)-furanone derivatives: p-TsOH/halotrimethylsilane promoted cycloketonization of γ-hydroxyl ynones†

Yi-Feng Qiu, ORCID logo *a   Jian-He Cao,a   Shutao Wang,b   Qiang Wang,a   Ming Li, ORCID logo a   Jun-Jiao Wang,a   Zheng-Jun Quan ORCID logo *a  and  Xi-Cun Wang ORCID logo *a  

* Corresponding authors

a College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, P. R. China
E-mail: qyfnet@nwnu.edu.cn, quanzj@nwnu.edu.cn, wangxicun@nwnu.edu.cn

b State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China

Abstract

A p-TsOH/halotrimethylsilane facilitated cycloketonization of γ-hydroxyl ynones is detailed. This methodology enables the one-step synthesis of polysubstituted 3(2H)-furanone products. It is remarkable that the reaction exhibits excellent regio- and chemoselectivity by the addition of very small quantities of p-toluenesulfonic acid and water.

Graphical abstract: Synthesis of 3(2H)-furanone derivatives: p-TsOH/halotrimethylsilane promoted cycloketonization of γ-hydroxyl ynones

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D3OB01500A
Article type
Paper
Submitted
18 Sep 2023
Accepted
18 Oct 2023
First published
19 Oct 2023

Org. Biomol. Chem., 2023,21, 8744-8748

Permissions

Request permissions

Synthesis of 3(2H)-furanone derivatives: p-TsOH/halotrimethylsilane promoted cycloketonization of γ-hydroxyl ynones

Y. Qiu, J. Cao, S. Wang, Q. Wang, M. Li, J. Wang, Z. Quan and X. Wang, Org. Biomol. Chem., 2023, 21, 8744 DOI: 10.1039/D3OB01500A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements