SCHEDULED MAINTENANCE
Unusual tellurium(iv) mediated cyclisation diols into dihydroxazoles with potential anticancer activity†
Pablo J.
Sanz Miguel 
d
and
Diego
Montagner
*a
d
and
Diego
Montagner
*a
Abstract
The role of tellurium in medicinal chemistry has recently grown in importance due to the discovery of the anticancer properties of SAS and AS-101, two inorganic compounds based on Te(IV). Here we describe an unprecedented isolation of a series of tetramethyl-dihydroxazole tellurium hexachloride salts whose structure has been indentified and characterised with several techniques including X-ray crystallography. The novelty resides on the role of tellurium that mediate the cyclisation of 1,1,2,2-tetramethylethylene into duhydroxazole in the presence of nitriles. Reaction mechanism, physiological stability and preliminary cytotoxicity results are discussed.
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