Issue 40, 2021, Issue in Progress
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RSC Advances

Development of an ultrafast fluorescent probe for specific recognition of hypochlorous acid and its application in live cells†

Zhencai Xu,‡ab   Xiaofeng Wang,‡a   Tingting Duan,a   Rong He,a   Fangwu Wanga  and  Xuejun Zhou ORCID logo *a  

* Corresponding authors

a Department of Otolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Hainan Medical University, Haikou 570102, China
E-mail: xuejunzhouent@hainmc.edu.cn

b Guanyun People's Hospital, Lianyungang 222000, China

Abstract

Hypochlorous acid (HOCl), a highly potent oxidant of reactive oxygen species, plays critical roles in many physiological and pathological processes. In this work, a novel coumarin-based fluorescent probe, Cou–HOCl, was prepared for the detection of HOCl. The probe exhibited good selectivity over other analytes, excellent sensitivity with a detection limit of 16 nM, and fast response within 5 s. And further study demonstrated that the probe could be used not only to image exogenous HOCl in various cells, but also to determine the fluctuating levels of HOCl in macrophage cells during inflammation.

Graphical abstract: Development of an ultrafast fluorescent probe for specific recognition of hypochlorous acid and its application in live cells

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Article information

DOI
https://doi.org/10.1039/D1RA04082K
Article type
Paper
Submitted
25 May 2021
Accepted
02 Jul 2021
First published
14 Jul 2021
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 24669-24672

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Development of an ultrafast fluorescent probe for specific recognition of hypochlorous acid and its application in live cells

Z. Xu, X. Wang, T. Duan, R. He, F. Wang and X. Zhou, RSC Adv., 2021, 11, 24669 DOI: 10.1039/D1RA04082K

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