Sustainability drives modern technology. Practices ensuring efficient resource utilization, guided resource handling and promotion of negative ecological footprint befittingly implicate “growth”. With manufacturing being one of the major contributing sectors to a nation's economy, adopting greener fabrication processes, the production of cleaner energy and the development of efficient products are important to achieve technological translation. Herein, a bi-functional hybrid (semiconductor–metal) system comprising zinc oxide nano leaves uniformly decorated with gold nano islands was synthesized using a one-step, room temperature biosynthetic reduction strategy. Being a one-step process, the number of reaction reagents and auxiliary byproducts was limited while material engineering ensured efficient product performance derived from coexistence of localized surface plasmon, semiconduction and their synergistic interaction. Detailed characterization of the as synthesized hybrid system concludes presence of defect states, crystalline nature, engineered band gap, pertinent chemical elemental state and interfacial charge distribution features. The hybrid nanostructures show strong surface-enhanced Raman scattering (SERS) characteristics for model R6G molecules (LOD: 10⁻¹⁰ M). Marked with the presence of symmetric and non-totally symmetric Raman vibrations, the role of electromagnetic and chemical enhancement was equally attributed to improved signal strengths. Contribution from charge transfer was verified using off resonance measurements and by studying the photolytic behavior of the nano-hybrid system. The self-cleaning feature of the nanohybrid was tested against a model bacterial contaminant S. aureus, which was killed with 100% efficiency using ∼60 μg ml⁻¹ under natural sunlight.