SCHEDULED MAINTENANCE
Catalytic asymmetric synthesis of optically active alkenes by palladium-catalysed asymmetric reduction of racemic allylic esters with formic acid
Abstract
Asymmetric reduction of racemic allyl ester, e.g. methyl 1-vinyl-1,2,3,4-tetrahydronaphth-1-yl carbonate, which contain two different alkyl groups at the α-position, with formic acid in the presence of 1 mol% of palladium catalyst coordinated with (R)-3-diphenylphosphino-3′-methoxy-4,4′-biphenanthryl [(R)-MOP-phen] ligand gives optically active terminal alkenes in up to 93% ee.
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