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Melanoma–role of the environment and genetics

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Abstract

Melanoma rates have increased in populations that are mainly European. The main etiologic factor is ultraviolet radiation, from the sun as well as artificial tanning devices. Host factors such as skin color, number of nevi, hair and eye color and tanning ability are critical factors in modifying an individual’s response to the sun. Genetic factors interact with host factors and environmental factors to increase risk. This review summarizes our current knowledge of environment and genetics on melanoma risk and on gene-environment interaction.

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Authors and Affiliations

  1. Cancer Epidemiology and Prevention Research, Sydney School of Public Health, The University of Sydney, Australia

    Anne Ε. Cust

  2. Melanoma Institute Australia, The University of Sydney, Australia

    Anne Ε. Cust

  3. University of New Mexico School of Medicine, Albuquerque, New Mexico, USA

    Kriti Mishra

  4. Division of Epidemiology, Biostatistics and Preventive Medicine, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico, USA

    Marianne Berwick

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  1. Anne Ε. Cust
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  2. Kriti Mishra
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  3. Marianne Berwick
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Correspondence to Marianne Berwick.

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Cust, A.Ε., Mishra, K. & Berwick, M. Melanoma–role of the environment and genetics. Photochem Photobiol Sci 17, 1853–1860 (2018). https://doi.org/10.1039/c7pp00411g

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  • DOI: https://doi.org/10.1039/c7pp00411g

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