Copper-catalyzed radical cascade oxyalkylation of olefinic amides with simple alkanes: highly efficient access to benzoxazines

Jie Wang; Ruoyu Sang; Xiaolong Chong; Yinuo Zhao; Wenjie Fan; Zejiang Li; Jincan Zhao

doi:10.1039/C7CC04213B

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Copper-catalyzed radical cascade oxyalkylation of olefinic amides with simple alkanes: highly efficient access to benzoxazines†

Jie Wang,^a Ruoyu Sang,^a Xiaolong Chong,^a Yinuo Zhao,^a Wenjie Fan,^a Zejiang Li^a and Jincan Zhao

*^ab

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* Corresponding authors

^a College of Chemistry & Environmental Science, Hebei University, Baoding, Hebei 071002, P. R. China
E-mail: jczhao@hbu.edu.cn

^b Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Hebei University, Baoding, Hebei 071002, P. R. China

Abstract

A copper-catalyzed C(sp³)–H bond functionalization of simple alkanes with olefinic amides was developed for the efficient synthesis of important benzoxazine derivatives. It involves new C–C and C–O bond formation in one step via a radical cascade process.

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Article information

DOI: https://doi.org/10.1039/C7CC04213B
Article type: Communication
Submitted: 31 May 2017
Accepted: 22 Jun 2017
First published: 22 Jun 2017

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Chem. Commun., 2017,53, 7961-7964

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Copper-catalyzed radical cascade oxyalkylation of olefinic amides with simple alkanes: highly efficient access to benzoxazines

J. Wang, R. Sang, X. Chong, Y. Zhao, W. Fan, Z. Li and J. Zhao, Chem. Commun., 2017, 53, 7961 DOI: 10.1039/C7CC04213B

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Chemical Communications

Copper-catalyzed radical cascade oxyalkylation of olefinic amides with simple alkanes: highly efficient access to benzoxazines†

Abstract

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Copper-catalyzed radical cascade oxyalkylation of olefinic amides with simple alkanes: highly efficient access to benzoxazines

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