CuI-catalyzed azide–alkyne cyclization (CuAAC) is the paradigmatic click reaction of continuous interest. Especially fluorogenic and FRET probes have become indispensable tools for life sciences. Here, we present a fluorescent alkyne for monitoring CuAAC, which undergoes a bathochromic shift upon reaction. Application in single-molecule and catalysis research is foreseen.
M. Wirtz, A. Grüter, P. Rebmann, T. Dier, D. A. Volmer, V. Huch and G. Jung, Chem. Commun., 2014, 50, 12694 DOI: 10.1039/C4CC05288A
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