Issue 7, 2013

A biopharmaceutical plant on a chip: continuous micro-devices for the production of monoclonal antibodies

Abstract

We report a proof-of-principle for the use of micro-devices as continuous bioreactors for the production of monoclonal antibodies. We culture CHO cells on the surface of PMMA “zigzag” channels textured with semi-spherical cavities coated with fibronectin, observing steady-state productivities 100 times higher than those observed in full scale systems.

Graphical abstract: A biopharmaceutical plant on a chip: continuous micro-devices for the production of monoclonal antibodies

Supplementary files

Article information

Article type
Communication
Submitted
02 Dec 2012
Accepted
23 Jan 2013
First published
11 Feb 2013

Lab Chip, 2013,13, 1243-1246

A biopharmaceutical plant on a chip: continuous micro-devices for the production of monoclonal antibodies

L. D. Garza-García, L. M. Carrillo-Cocom, D. Araiz-Hernández, P. Soto-Vázquez, J. López-Meza, E. J. Tapia-Mejía, S. Camacho-León, E. García-López, C. A. Rodríguez-González and M. M. Alvarez, Lab Chip, 2013, 13, 1243 DOI: 10.1039/C3LC50104C

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