Issue 20, 2014
From the journal:

Chemical Communications

Organometallic carbonyl clusters: a new class of contrast agents for photoacoustic cerebral vascular imaging†

Kien Voon Kong,‡a   Lun-De Liao,‡b   Zhiyong Lam,c   Nitish V. Thakor,bd   Weng Kee Leong*c  and  Malini Olivo*ae  

* Corresponding authors

a Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Singapore
E-mail: malini_olivo@sbic.a-star.edu.sg

b Singapore Institute for Neurotechnology (SINAPSE), National University of Singapore, Singapore

c Division of Chemistry & Biological Chemistry, Nanyang Technological University, Singapore
E-mail: chmlwk@ntu.edu.sg

d Department of Biomedical Engineering, John Hopkins University, USA

e School of Physics, National University of Ireland, Galway, Ireland

Abstract

We report, for the first time, the use of a water-soluble organometallic compound as a stable, reliable and high-contrast photoacoustic contrast agent. This gives a significantly higher contrast than that achievable with alternatives such as single-walled carbon nanotubes. Image enhancement of the rat cerebral cortex vasculature was observed using in vivo dark-field photoacoustic microscopy.

Graphical abstract: Organometallic carbonyl clusters: a new class of contrast agents for photoacoustic cerebral vascular imaging

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Article information

DOI
https://doi.org/10.1039/C3CC48529C
Article type
Communication
Submitted
08 Nov 2013
Accepted
16 Jan 2014
First published
16 Jan 2014

Chem. Commun., 2014,50, 2601-2603

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Organometallic carbonyl clusters: a new class of contrast agents for photoacoustic cerebral vascular imaging

K. V. Kong, L. Liao, Z. Lam, N. V. Thakor, W. K. Leong and M. Olivo, Chem. Commun., 2014, 50, 2601 DOI: 10.1039/C3CC48529C

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