Solid-phase peptide synthesis without acidolysis: the synthesis of thymosin α1 on a new benzhydrylamine resin
Abstract
The use of base-labile Nα-fluoren-9-ylmethoxy-carbonyl-substituted amino-acids, benzyl-based side-chain protecting groups, and a p-nitrobenzhydrylamine resin enabled solid-phase synthesis of thymosin α1 to be carried out under non-acidic, exceptionally mild conditions even in the final deprotecting step, which was performed by catalytic transfer hydrogenolysis with cyclohexa-1,4-diene.
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