Issue 32, 2012
From the journal:

RSC Advances

Poly(N-vinylimidazole) as a halogen-free and efficient catalyst for N-Boc protection of amines under solvent-free conditions†

Nader Ghaffari Khaligh*a  

* Corresponding authors

a House Research of Professor Reza. Education Guilan, Rasht, District 1, Iran
E-mail: ngkhaligh@guilan.ac.ir, ngkhaligh@gmail.com

Abstract

Poly(N-vinylimidazole) is able to promote the quantitative N-Boc protection of a variety of functionalized amines with t-butyl dicarbonate at room temperature under solvent-free conditions. This new method consistently has the advantage of providing excellent yields, while the catalyst is halogen-free and can be reused and recovered several times. Further, the reaction can be carried out even in a larger scale, making the procedure potentially useful for industrial applications.

Graphical abstract: Poly(N-vinylimidazole) as a halogen-free and efficient catalyst for N-Boc protection of amines under solvent-free conditions

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Article information

DOI
https://doi.org/10.1039/C2RA20905E
Article type
Paper
Submitted
10 May 2012
Accepted
16 Oct 2012
First published
19 Oct 2012

RSC Adv., 2012,2, 12364-12370

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Poly(N-vinylimidazole) as a halogen-free and efficient catalyst for N-Boc protection of amines under solvent-free conditions

N. G. Khaligh, RSC Adv., 2012, 2, 12364 DOI: 10.1039/C2RA20905E

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