Issue 2, 2013
From the journal:

Green Chemistry

Three-component stereoselective synthesis of spirooxindole derivatives†

Fuchao Yu,a   Rong Huang,a   Hangchen Ni,a   Juan Fan,a   Shengjiao Yan*a  and  Jun Lin*ab  

* Corresponding authors

a Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry Education, School of Chemical Science and Technology, Yunnan University, Kunming, P. R. China
E-mail: yansj@ynu.edu.cn, linjun@ynu.edu.cn
Fax: +86 871 5033215

b State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin, P. R. China

Abstract

A concise and efficient one-pot regio- and stereoselective synthesis of structurally diverse spirooxindoles was constructed by simply refluxing a mixture of different types of heterocyclic ketene aminals, isatins and ethyl trifluoroacetate using catalytic piperidine. The advantages of this method include high efficiency, mild reaction conditions and environmentally benign reagents. These spirooxindoles are promising candidates for drug discovery; consequently, a library of diverse spirooxindoles was rapidly constructed using the present protocol.

Graphical abstract: Three-component stereoselective synthesis of spirooxindole derivatives

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Article information

DOI
https://doi.org/10.1039/C2GC36552A
Article type
Paper
Submitted
01 Oct 2012
Accepted
20 Nov 2012
First published
20 Nov 2012

Green Chem., 2013,15, 453-462

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Three-component stereoselective synthesis of spirooxindole derivatives

F. Yu, R. Huang, H. Ni, J. Fan, S. Yan and J. Lin, Green Chem., 2013, 15, 453 DOI: 10.1039/C2GC36552A

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