Issue 9, 2012
From the journal:

Green Chemistry

An eco-friendly sequential catalyst- and solvent-free four-component stereoselective synthesis of novel 1,4-pyranonaphthoquinones†

Balasubramanian Devi Bala,a   Stephen Michael Rajesha  and  Subbu Perumal*a  

* Corresponding authors

a Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625021, India
E-mail: subbu.perum@gmail.com
Tel: +91 4522459845

Abstract

A series of novel highly functionalized 1,4-pyranonaphthoquinones has been synthesized stereoselectively from one-pot sequential reactions of anilines, diethyl acetylenedicarboxylate, 2-hydroxynaphthalene-1,4-dione and benzaldehydes under microwave irradiation. This solvent- and catalyst-free transformation affording biologically relevant heterocycles presumably involves two Michael additions, aldol condensation and annulation reactions.

Graphical abstract: An eco-friendly sequential catalyst- and solvent-free four-component stereoselective synthesis of novel 1,4-pyranonaphthoquinones

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Article information

DOI
https://doi.org/10.1039/C2GC35930H
Article type
Paper
Submitted
19 Jun 2012
Accepted
18 Jul 2012
First published
20 Jul 2012

Green Chem., 2012,14, 2484-2490

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An eco-friendly sequential catalyst- and solvent-free four-component stereoselective synthesis of novel 1,4-pyranonaphthoquinones

B. Devi Bala, S. Michael Rajesh and S. Perumal, Green Chem., 2012, 14, 2484 DOI: 10.1039/C2GC35930H

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