Issue 7, 2012

Drug development: longer-lived proteins

Abstract

Protein therapeutics represent a powerful class of clinically approved drugs for the prevention and treatment of various diseases. Once administered, the biological fate of protein therapeutics is governed by the body's various complex biochemical and biophysical clearance mechanisms, several of which may decrease the drug's circulation time and efficiency. In this tutorial review, we introduce the concepts of physiological protein clearance from the body, and describe several chemical modification and protein engineering approaches used to improve the life span of administered protein therapeutics.

Graphical abstract: Drug development: longer-lived proteins

  • This article is part of the themed collection: Nanomedicine

Article information

Article type
Tutorial Review
Submitted
24 Oct 2011
First published
06 Feb 2012

Chem. Soc. Rev., 2012,41, 2686-2695

Drug development: longer-lived proteins

S. Kontos and J. A. Hubbell, Chem. Soc. Rev., 2012, 41, 2686 DOI: 10.1039/C2CS15289D

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