Issue 6, 2011
From the journal:

Soft Matter

Biodegradable oligo(amidoamine/β-amino ester) hydrogels for controlled insulin delivery

Minh Khanh Nguyen,†‡a   Cong Truc Huynh,†a   Guang Hui Gao,a   Ji Hyun Kim,a   Dai Phu Huynh,ab   Su Young Chae,c   Kang Choon Leec  and  Doo Sung Lee*a  

* Corresponding authors

a Theranostic Macromolecules Research Center, Department of Polymer Science and Engineering, Sungkyunkwan University, Suwon, Gyeonggi-do, Korea
E-mail: dslee@skku.edu
Fax: +82-31-292-8790
Tel: +82-31-290-7282

b National Key Laboratory of Polymer and Composite Materials, HoChiMinh City University of Technology, 268 LyThuongKiet, Dist. 10, HoChiMinh City, Vietnam

c College of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do, Korea

Abstract

An injectable biodegradable hydrogel system based on oligo(amidoamine/β-amino ester) (OAAAE) was designed and synthesized for controlled release of insulin under the physiological conditions. OAAAE was prepared in one step via the Michael-addition oligomerization of the secondary amine groups of 4,4-trimethylene dipiperidine (TMDP) with the vinyl groups of 1,8-octylene diacrylamide (ODA) and 1,6-hexane diol diacrylate (HDA). The formed oligomer was characterized by 1H NMR and gel permeation chromatography (GPC). OAAAE in aqueous solution (20 wt%) underwent a gel–sol transition in the pH range of 6.8–7.4. A complex hydrogel was formed when mixing insulin with the oligomer solution followed by increasing pH and temperature. Degradation of the hydrogel, influence of insulin on gel phase and gel strength, in vitro cytotoxicity of OAAAE, in vitro and in vivo release of insulin from the complex hydrogel were investigated. Furthermore, the in vivo release profile of insulin from the complex hydrogel was compared with that from the neutral hydrogel.

Graphical abstract: Biodegradable oligo(amidoamine/β-amino ester) hydrogels for controlled insulin delivery

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/C0SM01285H
Article type
Paper
Submitted
09 Nov 2010
Accepted
06 Jan 2011
First published
01 Feb 2011

Soft Matter, 2011,7, 2994-3001

Permissions

Request permissions

Biodegradable oligo(amidoamine/β-amino ester) hydrogels for controlled insulin delivery

M. K. Nguyen, C. T. Huynh, G. H. Gao, J. H. Kim, D. P. Huynh, S. Y. Chae, K. C. Lee and D. S. Lee, Soft Matter, 2011, 7, 2994 DOI: 10.1039/C0SM01285H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements