Issue 14, 2010
From the journal:

Journal of Materials Chemistry

Highly PEGylated silicananoparticles: “ready to use” stealth functional nanocarriers

Iria Maria Rio-Echevarria,ab   Francesco Selvestrel,ab   Daniela Segat,b   Gaetano Guarino,a   Regina Tavano,c   Valerio Causin,a   Elena Reddi,b   Emanuele Papini*c  and  Fabrizio Mancin*a  

* Corresponding authors

a Dipartimento di Scienze Chimiche, Università di Padova, via Marzolo 1, Padova, Italy
E-mail: fabrizio.mancin@unipd.it
Fax: +39 0498275666
Tel: +39 0498275239

b Dipartimento di Biologia, Università di Padova, via U. Bassi 58/B, Padova

c Dipartimento di Scienze Biomediche e Centro di Ricerca Interdipartimentale per le Biotecnologie Innovative, Università di Padova, via U. Bassi 58/B, Padova
E-mail: emanuele.papini@unipd.it
Fax: +39 0498276301
Tel: +39 0498276159

Abstract

The peculiar properties of silica nanoparticles make them well suited to the development of smart nanomaterials for medicine. Here we report a new procedure to prepare doped and PEGylated silica-based nanoparticles. Thus, a complex multifunctional system is obtained simply by a one-pot reaction followed by a straightforward purification procedure. Control of the nanoparticles final size is obtained by carefully choosing reactants and conditions. Moreover, reactive functional groups necessary to allow subsequent bioconjugation are easily introduced in the PEG coating by the same procedure. Unprecedented high-density surface coating is obtained and this successfully stabilizes the nanoparticles against aggregation both in saline solution and in the presence of serum proteins. The absence of cytotoxicity and “stealth” behaviour toward phagocytic capture by human macrophages has been demonstrated and this enables such nanosystems as candidates for the development of drug delivery agents.

Graphical abstract: Highly PEGylated silica nanoparticles: “ready to use” stealth functional nanocarriers

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Article information

DOI
https://doi.org/10.1039/B921735E
Article type
Paper
Submitted
20 Oct 2009
Accepted
04 Jan 2010
First published
11 Feb 2010

J. Mater. Chem., 2010,20, 2780-2787

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Highly PEGylated silica nanoparticles: “ready to use” stealth functional nanocarriers

I. M. Rio-Echevarria, F. Selvestrel, D. Segat, G. Guarino, R. Tavano, V. Causin, E. Reddi, E. Papini and F. Mancin, J. Mater. Chem., 2010, 20, 2780 DOI: 10.1039/B921735E

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