Issue 4, 2009
From the journal:

Organic & Biomolecular Chemistry

Inhibition of Acinetobacter baumannii, Staphylococcus aureus and Pseudomonas aeruginosabiofilm formation with a class of TAGE-triazole conjugates†

Robert W. Huigens III,a   Steven A. Rogers,a   Andrew T. Steinhauera  and  Christian Melander*a  

* Corresponding authors

a North Carolina State University Chemistry Department, 2620 Yarborough Drive, Raleigh, North Carolina, United States of America

Abstract

A chemically diverse library of TAGE-triazole conjugates was synthesized utilizing click chemistry on the TAGE scaffold. This library of small molecules was screened for anti-biofilm activity and found to possess the ability of inhibiting biofilm formation against Acinetobacter baumannii, Staphylococcus aureus and Pseudomonas aeruginosa. One such compound in this library demonstrated the most potent inhibitory effect against Staphylococcus aureus biofilm formation that has been displayed by any 2-aminoimidazole derivative.

Graphical abstract: Inhibition of Acinetobacter baumannii, Staphylococcus aureus and Pseudomonas aeruginosa biofilm formation with a class of TAGE-triazole conjugates

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B817926C
Article type
Paper
Submitted
13 Oct 2008
Accepted
20 Nov 2008
First published
12 Jan 2009

Org. Biomol. Chem., 2009,7, 794-802

Permissions

Request permissions

Inhibition of Acinetobacter baumannii, Staphylococcus aureus and Pseudomonas aeruginosa biofilm formation with a class of TAGE-triazole conjugates

R. W. Huigens III, S. A. Rogers, A. T. Steinhauer and C. Melander, Org. Biomol. Chem., 2009, 7, 794 DOI: 10.1039/B817926C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements