Issue 22, 2006
From the journal:

Chemical Communications

Two novel non-viral gene delivery vectors: low molecular weight polyethylenimine cross-linked by (2-hydroxypropyl)-β-cyclodextrin or (2-hydroxypropyl)-γ-cyclodextrin†

Hongliang Huang,‡a   Guping Tang,‡b   Qingqing Wang,*a   Da Li,a   Fenping Shen,a   Jun Zhoub  and  Hai Yu*a  

* Corresponding authors

a Institute of Immunology, Zhejiang University, P. R. China
E-mail: yuhai@zju.edu.cn, wqq@zju.edu.cn
Fax: (+86) 571 87217044
Tel: (+86) 571 87217008

b Institute of Chemical Biology and Pharmaceutical Chemistry, Zhejiang University, P. R. China
E-mail: tangguping@yahoo.com.cn
Tel: (+86) 571 88273284

Abstract

Two novel polymers of low molecular weight polyethylenimine cross-linked by (2-hydroxypropyl)-β-cyclodextrin or (2-hydroxypropyl)-γ-cyclodextrin showed lower cytotoxicity and higher transfection efficiency for the delivery of plasmid DNA compared with those of polyethylenimine (PEI, 25 kDa).

Graphical abstract: Two novel non-viral gene delivery vectors: low molecular weight polyethylenimine cross-linked by (2-hydroxypropyl)-β-cyclodextrin or (2-hydroxypropyl)-γ-cyclodextrin

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Article information

DOI
https://doi.org/10.1039/B601130F
Article type
Communication
Submitted
24 Jan 2006
Accepted
28 Feb 2006
First published
22 Mar 2006

Chem. Commun., 2006, 2382-2384

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Two novel non-viral gene delivery vectors: low molecular weight polyethylenimine cross-linked by (2-hydroxypropyl)-β-cyclodextrin or (2-hydroxypropyl)-γ-cyclodextrin

H. Huang, G. Tang, Q. Wang, D. Li, F. Shen, J. Zhou and H. Yu, Chem. Commun., 2006, 2382 DOI: 10.1039/B601130F

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