Issue 10, 2003
From the journal:

Organic & Biomolecular Chemistry

Suzuki cross-coupling mediated by tetradentate N-heterocyclic carbene (NHC)–palladium complexes in an environmentally benign solvent†

Yuanhong Zhao,a   Yongyun Zhou,a   Dandan Ma,a   Jingping Liu,a   Liang Li,a   Tony Y. Zhangb  and  Hongbin Zhang*a  

* Corresponding authors

a School of Pharmacy, Yunnan University, Kunming, Yunnan 650091, P. R. China
E-mail: zhang_hongbin@hotmail.com
Tel: 86 871 5031119

b Chemical Process Research and Development, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285-4813, USA

Abstract

A highly effective, easy to handle and environmentally benign process for palladium mediated Suzuki cross-coupling was developed. By utilizing a solid support based NHC–palladium catalyst, cross couplings of aryl bromides with phenylboronic acid were achieved in neat water under air. A high ratio of substrate to catalyst was also realized.

Graphical abstract: Suzuki cross-coupling mediated by tetradentate N-heterocyclic carbene (NHC)–palladium complexes in an environmentally benign solvent

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Article information

DOI
https://doi.org/10.1039/B302646A
Article type
Communication
Submitted
10 Mar 2003
Accepted
22 Apr 2003
First published
25 Apr 2003

Org. Biomol. Chem., 2003,1, 1643-1646

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Suzuki cross-coupling mediated by tetradentate N-heterocyclic carbene (NHC)–palladium complexes in an environmentally benign solvent

Y. Zhao, Y. Zhou, D. Ma, J. Liu, L. Li, T. Y. Zhang and H. Zhang, Org. Biomol. Chem., 2003, 1, 1643 DOI: 10.1039/B302646A

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