Issue 6, 2001
From the journal:

Green Chemistry

Solvent-free, two-step synthesis of some unsymmetrical 4-aryl-1,4-dihydropyridines

Waldo H. Correaa  and  Janet L. Scott*a  

* Corresponding authors

a Centre for Green Chemistry, P.O. Box 23, Monash University, Victoria, Australia.
E-mail: janet.scott@sci.monash.edu.au

Abstract

4-Aryl-1,4-dihydropyridines are efficiently synthesised under solvent-free conditions in high yield. The use of volatile solvents is restricted to recrystallisation of the product, which, due to the high degree of conversion, is kept to a minimum. Optimisation of reaction conditions by careful consideration of the reaction rate and extent of conversion is demonstrated. This is yet another example of how readily solvent-free reactions may be implemented in the highly reproducible and efficient preparation of pure therapeutic agents with minimal production of waste and optimised use of energy.

Graphical abstract: Solvent-free, two-step synthesis of some unsymmetrical 4-aryl-1,4-dihydropyridines

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B106397A
Article type
Paper
Submitted
18 Jul 2001
First published
30 Oct 2001

Green Chem., 2001,3, 296-301

Permissions

Request permissions

Solvent-free, two-step synthesis of some unsymmetrical 4-aryl-1,4-dihydropyridines

W. H. Correa and J. L. Scott, Green Chem., 2001, 3, 296 DOI: 10.1039/B106397A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements