Issue 5, 2001
From the journal:

Chemical Communications

Synthesis of novel non-cross-linking pyrrolobenzodiazepines with remarkable DNA binding affinity and potent antitumour activity

Ahmed Kamal,*a   N. Laxman,a   G. Ramesh,a   K. Neelimab  and  Anand K. Kondapib  

* Corresponding authors

a Division of Organic Chemistry, Indian Institute of Chemical Technology, 500 007, Hyderabad, India.
E-mail: ahmedkamal@iict.ap.nic.in

b Department of Biochemistry, School of Life Sciences, University of Hyderabad, 500 046, Hyderabad, India

Abstract

Mixed imine–amide pyrrolobenzodiazepine dimers have been prepared which exhibit potent antitumour activity and have significant DNA binding affinity; one of them, 1c, has been shown to cause a remarkable rise in the melting temperature of calf thymus DNA.

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Article information

DOI
https://doi.org/10.1039/B009195M
Article type
Communication
Submitted
16 Nov 2000
Accepted
23 Jan 2001
First published
13 Feb 2001

Chem. Commun., 2001, 437-438

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Synthesis of novel non-cross-linking pyrrolobenzodiazepines with remarkable DNA binding affinity and potent antitumour activity

A. Kamal, N. Laxman, G. Ramesh, K. Neelima and A. K. Kondapi, Chem. Commun., 2001, 437 DOI: 10.1039/B009195M

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